Role Overview
We are seeking a hands-on Senior Research Scientist to lead the development and application of cell-based assays and three-dimensional tissue models within Pandorum’s Cellular Engineering team. The position combines mammalian cell culture, disease-relevant model development, biochemical analysis and evaluation of biological activity.
Required Qualifications
- Ph.D. in Biotechnology, Cell Biology, Molecular Biology, Biochemistry, Bioengineering, Regenerative Medicine, Stem Cell Biology, Pharmacology, Neuroscience or a related life-science discipline.
Experience: Typically 3–6 years of relevant post-Ph.D. research or industry experience; demonstrated scientific independence and directly relevant expertise will guide assessment..
Key Responsibilities
- Perform biochemical, molecular and cell-based assays; analyze results and maintain complete laboratory records.
- Design controlled experiments with predefined objectives, appropriate comparators and biological replication; retain complete records and critically assess all findings.
- Establish, maintain and characterize human cellular, multicellular and 3D tissue models, including spheroids or organoids appropriate to the research question.
- Develop and qualify assays for biological activity in disease-relevant systems, drawing on expertise in inflammation, fibrosis and tissue repair.
- Characterize experimental materials using appropriate biochemical and molecular methods, and perform quantitative cell-based assays.
- Evaluate concentration-dependent and time-dependent responses, model reproducibility and tissue-relevant function alongside viability and appropriate controls.
- Work with colleagues to investigate assay variability, establish suitable controls and improve method reproducibility.
- Prepare technical reports, present findings and contribute to assay transfer and preclinical study documentation.
- Own experimental plans and milestones, maintain SOPs and technical reports, communicate findings clearly and mentor junior team members.
Preferred Experience
- Experience with quantitative imaging, molecular assays and integration of structural and functional readouts; assay transfer or collaboration with external research laboratories.
- Strong hands-on mammalian cell-culture, cell-biology and molecular-biology skills, with evidence of independent experimental design, troubleshooting and quantitative data interpretation.
- Ability to perform and interpret biochemical or molecular characterization alongside quantitative cell-based assays, with clear documentation and scientific communication.
- Demonstrated independent ownership of disease-relevant assay development, including hands-on establishment and characterization of at least one human 3D culture, spheroid, organoid or multicellular tissue model.
- Scientific depth in inflammation, fibrosis, tissue repair, neurobiology or a related area, with the ability to apply that expertise across experimental systems.
- Working understanding of cellular signaling, gene expression and molecular mechanisms relevant to cell-based research.
- Experience with organoid development, stem-cell differentiation or advanced human co-culture models.
- Experience with induced pluripotent stem cell (iPSC) maintenance and characterization, directed differentiation, or neuronal/glial cultures.
- Experience with extracellular-vesicle (EV) biology, biochemical characterization or functional and potency assays.
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